Disrupted HSF1 regulation in normal and exceptional brain aging.

ABSTRACT: Brain aging is a major risk factor for cognitive diseases such as Alzheimer's disease (AD) and vascular dementia. The rate of aging and age-related pathology are modulated by stress responses and repair pathways that gradually decline with age. However, recent reports indicate that exceptional longevity sustains and may even enhance the stress response. Whether normal and exceptional aging result in either attenuated or enhanced stress responses across all organs is unknown. This question arises from our understanding that biological age differs from chronological age and evidence that the rate of aging varies between organs. Thus, stress responses may differ between organs and depend upon regenerative capacity and ability to manage damaged proteins and proteotoxicity. To answer these ques

SUBMITTER: Trivedi R 

PROVIDER: S-EPMC10794279 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature