Local fractal dimension of collagen detects increased spatial complexity in fibrosis.

ABSTRACT: Increase of collagen content and reorganization characterizes fibrosis but quantifying the latter remains challenging. Spatially complex structures are often analyzed via the fractal dimension; however, established methods for calculating this quantity either provide a single dimension for an entire object or a spatially distributed dimension that only considers binary images. These neglect valuable information related to collagen density in images of fibrotic tissue. We sought to develop a fractal analysis that can be applied to 3-dimensional (3D) images of fibrotic tissue. A fractal dimension map for each image was calculated by determining a single fractal dimension for a small area surrounding each image pixel, using fiber thickness as the third dimension. We found that this local frac

SUBMITTER: Casey DT 

PROVIDER: S-EPMC10794291 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature