Recombination map tailored to Native Hawaiians may improve robustness of genomic scans for positive selection.

ABSTRACT: Recombination events establish the patterns of haplotypic structure in a population and estimates of recombination rates are used in several downstream population and statistical genetic analyses. Using suboptimal maps from distantly related populations may reduce the efficacy of genomic analyses, particularly for underrepresented populations such as the Native Hawaiians. To overcome this challenge, we constructed recombination maps using genome-wide array data from two study samples of Native Hawaiians: one reflecting the current admixed state of Native Hawaiians (NH map) and one based on individuals of enriched Polynesian ancestries (PNS map) with the potential to be used for less admixed Polynesian populations such as the Samoans. We found the recombination landscape to be less correlat

SUBMITTER: Dinh BL 

PROVIDER: S-EPMC10794367 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature