Impact of plastic-related compounds on the gene expression signature of HepG2 cells transfected with CYP3A4.

ABSTRACT: The presence of plastic and microplastic within the oceans as well as in marine flora and fauna have caused a multitude of problems that have been the topic of numerous investigations for many years. However, their impact on human health remains largely unknown. Such plastic and microplastic particles have been detected in blood and placenta, underlining their ability to enter the human body. Plastics also contain other compounds, such as plasticizers, antioxidants, or dyes, whose impact on human health is currently being studied. Critical enzymes within the metabolism of endogenous molecules, especially of xenobiotics, are the cytochrome P450 monooxygenases (CYPs). Although their importance in maintaining cellular balance has been confirmed, their interactions with plastics and related pr

SUBMITTER: Rosellini M 

PROVIDER: S-EPMC10794370 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature