Exploring the causal role of gut microbiota in giant cell arteritis: a Mendelian randomization analysis with mediator insights.

ABSTRACT:

Background

Giant Cell Arteritis (GCA) is a complex autoimmune condition. With growing interest in the role of gut microbiota in autoimmune diseases, this research aimed to explore the potential causal relationship between gut microbiota and GCA, and the mediating effects of specific intermediaries.

Methods

Using a bidirectional two-sample Mendelian randomization (MR) design, we investigated associations between 191 microbial taxa and GCA. A two-step MR technique discerned the significant mediators on this relationship, followed by Multivariable MR analyses to quantify the direct influence of gut microbiota on GCA and mediation effect proportion, adjusting for these mediators.

Results

Nine taxa displayed significant associations with GCA. Among them, families like Bact

SUBMITTER: Wu M 

PROVIDER: S-EPMC10794469 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature