Evaluation of tractography-based myelin-weighted connectivity across the lifespan.

ABSTRACT:

Introduction

Recent studies showed that the myelin of the brain changes in the life span, and demyelination contributes to the loss of brain plasticity during normal aging. Diffusion-weighted magnetic resonance imaging (dMRI) allows studying brain connectivity in vivo by mapping axons in white matter with tractography algorithms. However, dMRI does not provide insight into myelin; thus, combining tractography with myelin-sensitive maps is necessary to investigate myelin-weighted brain connectivity. Tractometry is designated for this purpose, but it suffers from some serious limitations. Our study assessed the effectiveness of the recently proposed Myelin Streamlines Decomposition (MySD) method in estimating myelin-weighted connectomes and its capacity to

SUBMITTER: Bosticardo S 

PROVIDER: S-EPMC10794573 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature