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Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176.

ABSTRACT: Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein.

SUBMITTER: Konings M

PROVIDER: S-EPMC10794591 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176.

Konings Mickey M Gerrits van den Ende Bert B Raats Mirthe W J MWJ Fahal Ahmed Hassan AH van de Sande Wendy W J WWJ Hagen Ferry F

Mycopathologia 20240117 1

Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M. fahalii type-strain CBS 129176 genome assembly and annotation to identify a glutamic acid insert near the azole-binding pocket in the Cyp51A protein. ...[more]

PMID: 38231295

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