Association between suicidal ideation and tandem repeats in contactins.

ABSTRACT:

Background

Death by suicide is one of the leading causes of death among adolescents. Genome-wide association studies (GWAS) have identified loci that associate with suicidal ideation and related behaviours. One such group of loci are the six contactin genes (CNTN1-6) that are critical to neurodevelopment through regulating neurite structure. Because single nucleotide polymorphisms (SNPs) detected by GWAS often map to non-coding intergenic regions, we investigated whether repetitive variants in CNTNs associated with suicidality in a young cohort aged 8 to 21. Understanding the genetic liability of suicidal thought and behavior in this age group will promote early intervention and treatment.

Methods

Genotypic and phenotypic data were obtained from the Phil

SUBMITTER: Parikh K 

PROVIDER: S-EPMC10794671 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature