Phytochemical and biological studies of Panicum antidotale aerial parts ethanol extract supported by molecular docking study.

ABSTRACT: Panicum antidotale has traditionally been used as a poultice to alleviate local inflammation and painful diseases. This study aimed to evaluate the anti-inflammatory, wound-healing, analgesic, and antipyretic potential of its ethanol extract (PAAPEE) in vivo for the first time. In vitro antioxidant assays of Panicum antidotale using a 2,2-diphenyl-1-picrylhydrazyl assay revealed that it showed IC₅₀ of 62.50 ± 6.85 μg/mL in contrast to standard, ascorbic acid, that showed IC₅₀ of 85.51 ± 0.38 μg/mL. Administration of PAAPEE at a dose of 500 mg/kg (PAAPEE-500) displayed 78.44% and 75.13% inhibition of paw edema in carrageenen and histamine-induced edema models. respectively, 6 h post-treatment compared to that of the untreated group. Furtherm

SUBMITTER: Sarwar I 

PROVIDER: S-EPMC10794742 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature