Spatiotemporal DNA methylation dynamics shape megabase-scale methylome landscapes.

ABSTRACT: DNA methylation is an essential epigenetic mechanism that regulates cellular reprogramming and development. Studies using whole-genome bisulfite sequencing have revealed distinct DNA methylome landscapes in human and mouse cells and tissues. However, the factors responsible for the differences in megabase-scale methylome patterns between cell types remain poorly understood. By analyzing publicly available 258 human and 301 mouse whole-genome bisulfite sequencing datasets, we reveal that genomic regions rich in guanine and cytosine, when located near the nuclear center, are highly susceptible to both global DNA demethylation and methylation events during embryonic and germline reprogramming. Furthermore, we found that regions that generate partially methylated domains during global DNA meth

SUBMITTER: Toh H 

PROVIDER: S-EPMC10794778 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature