The human Y and inactive X chromosomes similarly modulate autosomal gene expression.

ABSTRACT: Somatic cells of human males and females have 45 chromosomes in common, including the "active" X chromosome. In males the 46^th chromosome is a Y; in females it is an "inactive" X (Xi). Through linear modeling of autosomal gene expression in cells from individuals with zero to three Xi and zero to four Y chromosomes, we found that Xi and Y impact autosomal expression broadly and with remarkably similar effects. Studying sex chromosome structural anomalies, promoters of Xi- and Y-responsive genes, and CRISPR inhibition, we traced part of this shared effect to homologous transcription factors-ZFX and ZFY-encoded by Chr X and Y. This demonstrates sex-shared mechanisms by which Xi and Y modulate autosomal expression. Combined with earlier analyses of sex-linked gene expression, our s

SUBMITTER: San Roman AK 

PROVIDER: S-EPMC10794785 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature