Digital Clock Drawing as an Alzheimer's Disease Susceptibility Biomarker: Associations with Genetic Risk Score and APOE in Older Adults.

ABSTRACT:

Background

Alzheimer's disease (AD) is the leading cause of dementia in older adults, but most people are not diagnosed until significant neuronal loss has likely occurred along with a decline in cognition. Non-invasive and cost-effective digital biomarkers for AD have the potential to improve early detection.

Objective

We examined the validity of DCTclockTM (a digitized clock drawing task) as an AD susceptibility biomarker.

Design

We used two primary independent variables, Apolipoprotein E (APOE) ε4 allele carrier status and polygenic risk score (PRS). We examined APOE and PRS associations with DCTclockTM composite scores as dependent measures.

Setting

We used existing data from the Framingham Heart Study (FHS), a community-based study with the largest dataset

SUBMITTER: Thompson LI 

PROVIDER: S-EPMC10794851 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature