Surface Oxygen Deficiency Enabled Spontaneous Antiprotein Fouling in WO₃ Nanosheets for Biosensing in Biological Fluids.

ABSTRACT: Biofouling deteriorates the performance of sensors operated in biofluids. Protein adsorption is believed to be the first step of biofouling, which also reduces biocompatibility by further inducing cell adhesion, platelet activation, and even inflammation. Current studies of antifouling coatings are focused on polymers and hydrogels, which have succeeded in remaining resistant to protein adsorption, but their application on sensor electrodes is limited due to low conductivity and biocompatibility. Here, we report a spontaneous antibiofouling strategy for sensor electrodes by controlling oxygen vacancies in WO₃ nanosheets. Irreversible adsorption of proteins was reduced by 76% in unprocessed human plasma when electrodes were coated with WO₃ rich in surface oxygen vacanc

SUBMITTER: He G 

PROVIDER: S-EPMC10794997 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature