β-Hairpin Alignment Alters Oligomer Formation in Aβ-Derived Peptides.

ABSTRACT: Amyloid-β (Aβ) forms heterogeneous oligomers, which are implicated in the pathogenesis of Alzheimer's disease (AD). Many Aβ oligomers consist of β-hairpin building blocks─Aβ peptides in β-hairpin conformations. β-Hairpins of Aβ can adopt a variety of alignments, but the role that β-hairpin alignment plays in the formation and heterogeneity of Aβ oligomers is poorly understood. To explore the effect of β-hairpin alignment on the oligomerization of Aβ peptides, we designed and studied two model peptides with two different β-hairpin alignments. Peptides Aβm_17-36 and Aβm_17-35 mimic two different β-hairpins that Aβ can form, the Aβ_17-36 and Aβ_17-35 β-hairpins, respectively. These hairpins are similar in composition but differ in hairpin alignment, alt

SUBMITTER: Ruttenberg SM 

PROVIDER: S-EPMC10795187 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature