A formula for predicting emphysema extent in combined idiopathic pulmonary fibrosis and emphysema.

ABSTRACT:

Background

No single pulmonary function test captures the functional effect of emphysema in idiopathic pulmonary fibrosis (IPF). Without experienced radiologists, other methods are needed to determine emphysema extent. Here, we report the development and validation of a formula to predict emphysema extent in patients with IPF and emphysema.

Methods

The development cohort included 76 patients with combined IPF and emphysema at the Royal Brompton Hospital, London, United Kingdom. The formula was derived using stepwise regression to generate the weighted combination of pulmonary function data that fitted best with emphysema extent on high-resolution computed tomography. Test cohorts included patients from two clinical trials (n = 455 [n = 174 with emphysema]; NCT00047645, NCT00

SUBMITTER: Wells AU 

PROVIDER: S-EPMC10795205 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature