TIPARP as a prognostic biomarker and potential immunotherapeutic target in male papillary thyroid carcinoma.

ABSTRACT:

Background

Male patients with papillary thyroid carcinoma (PTC) tend to have poorer prognosis compared to females, partially attributable to a higher rate of lymph node metastasis (LNM). Developing a precise predictive model for LNM occurrence in male PTC patients is imperative. While preliminary predictive models exist, there is room to improve accuracy. Further research is needed to create optimized prognostic models specific to LNM prediction in male PTC cases.

Methods

We conducted a comprehensive search of publicly available microarray datasets to identify candidate genes continuously upregulated or downregulated during PTC progression in male patients only. Univariate Cox analysis and lasso regression were utilized to construct an 11-gene signature predictive of LNM. TI

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10795290 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature