Single-cell analysis of the cellular landscape of vulvar melanoma provides new insight for immunotherapy administration.

ABSTRACT:

Background

Vulvar and vaginal melanoma (VuM & VaM) is a rare gynecologic malignancy with high mortality but low effectiveness to checkpoint immunotherapy compared to cutaneous melanoma. This article aims to elucidate the role of the disordered immune microenvironment in cancer progression in VuM.

Methods

At first, this article applied single-cell RNA sequencing (scRNA-seq) to the VuM obtained from a 68-year-old female patient, and constructed a single-cell atlas of VuM consist of 12,243 single cells. Then this article explores the genomic complexity and core signal channel in VuM microenvironment.

Results

This article provides new insights about the pathogenesis of VuM based on single-cell resolution data. It was found that the activation of CD8⁺ T cell con

SUBMITTER: Wang X 

PROVIDER: S-EPMC10795381 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature