Alterations in gut and genital microbiota associated with gynecological diseases: a systematic review and meta-analysis.

ABSTRACT:

Background

Increasing number of studies have demonstrated certain patterns of microbial changes in gynecological diseases; however, the interaction between them remains unclear. To evaluate the consistency or specificity across multiple studies on different gynecological diseases and microbial alterations at different sites of the body (gut and genital tract), we conducted a systematic review and meta-analysis.

Methods

We searched PubMed, Embase, Web of Science, and Cochrane Library up to December 5, 2022(PROSPERO: CRD42023400205). Eligible studies focused on gynecological diseases in adult women, applied next-generation sequencing on microbiome, and reported outcomes including alpha or beta diversity or relative abundance. The random-effects model on standardized mean diffe

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC10795389 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature