METTL3 drives NSCLC metastasis by enhancing CYP19A1 translation and oestrogen synthesis.

ABSTRACT:

Background

METTL3 plays a significant role as a catalytic enzyme in mediating N6-methyladenosine (m⁶A) modification, and its importance in tumour progression has been extensively studied in recent years. However, the precise involvement of METTL3 in the regulation of translation in non-small cell lung cancer (NSCLC) remains unclear.

Results

Here we discovered by clinical investigation that METTL3 expression is correlated with NSCLC metastasis. Ablation of METTL3 in NSCLC cells inhibits invasion and metastasis in vitro and in vivo. Subsequently, through translatomics data mining and experimental validation, we demonstrated that METTL3 enhances the translation of aromatase (CYP19A1), a key enzyme in oestrogen synthesis, thereby promoting oestrogen production and med

SUBMITTER: Meng W 

PROVIDER: S-EPMC10795463 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature