Pharmaco-EEG analysis of ligands varying in selectivity for α1 subunit-containing GABA_A receptors during the active phase in rats.

ABSTRACT:

Rationale

Benzodiazepines are known to evoke changes in cortical electrophysiological activity that can be correlated with action at distinct γ-aminobutyric acid type A (GABA_A) receptor subtypes.

Objectives

We used electroencephalography (EEG) paired with electromyography (EMG) to evaluate the role of α1 subunit-containing GABA_A receptors (α1GABA_ARs) in benzodiazepine-induced sedation and changes in EEG band frequencies during the active phase of the light/dark cycle.

Methods

Male Sprague-Dawley rats (N = 4/drug) were surgically instrumented with EEG/EMG electrodes. The rats were injected i.p. with zolpidem, an α1GABA_AR-preferring compound, or L-838,417, which has selective efficacy for α2/3/5 subunit-containing GABA_A</

SUBMITTER: Reeves-Darby JA 

PROVIDER: S-EPMC10795493 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature