High-throughput ultrasound neuromodulation in awake and freely behaving rats.

ABSTRACT: Transcranial ultrasound neuromodulation is a promising potential therapeutic tool for the noninvasive treatment of neuropsychiatric disorders. However, the expansive parameter space and difficulties in controlling for peripheral auditory effects make it challenging to identify ultrasound sequences and brain targets that may provide therapeutic efficacy. Careful preclinical investigations in clinically relevant behavioral models are critically needed to identify suitable brain targets and acoustic parameters. However, there is a lack of ultrasound devices allowing for multi-target experimental investigations in awake and unrestrained rodents. We developed a miniaturized 64-element ultrasound array that enables neurointerventional investigations with within-trial active control targets in fr

SUBMITTER: Di Ianni T 

PROVIDER: S-EPMC10795522 | biostudies-literature | 2023 Nov-Dec

REPOSITORIES: biostudies-literature