Sick individuals, sick populations revisited: a test of the Rose hypothesis for type 2 diabetes disparities.

ABSTRACT:

Introduction

The Rose hypothesis predicts that since genetic variation is greater within than between populations, genetic risk factors will be associated with individuals' risk of disease but not population disparities, and since socioenvironmental variation is greater between than within populations, socioenvironmental risk factors will be associated with population disparities but not individuals' disease risk.

Methods

We used the UK Biobank to test the Rose hypothesis for type 2 diabetes (T2D) ethnic disparities in the UK. Our cohort consists of 26 912 participants from Asian, black and white ethnic groups. Participants were characterised as T2D cases or controls based on the presence or absence of T2D diagnosis codes in electronic health records. T2D genetic risk was me

SUBMITTER: Gupta S 

PROVIDER: S-EPMC10795613 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature