Association of smoking with amyotrophic lateral sclerosis: A systematic review, meta-analysis, and dose-response analysis.

ABSTRACT:

Introduction

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder primarily affecting the voluntary motor nervous system. Several observational studies have provided conflicting results regarding the association between smoking and ALS. Therefore, our objective was to investigate this association through a systematic review, meta-analysis, and dose-response analysis.

Methods

On 16 January 2023, we initially extracted records from medical databases, which included Medline, Embase, Web of Science, Scopus, and ScienceDirect. We included case-control and cohort studies as eligible studies. Subgroup analyses were performed based on sex, study design, and current smoking. Restricted cubic-spline analysis was utilized to assess the dose-response relations

SUBMITTER: Kim K 

PROVIDER: S-EPMC10795623 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature