Quantification of Glomerular Structural Lesions: Associations With Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome.

ABSTRACT:

Rationale & objective

The current classification system for focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) does not fully capture the complex structural changes in kidney biopsies nor the clinical and molecular heterogeneity of these diseases.

Study design

Prospective observational cohort study.

Setting & participants

221 MCD and FSGS patients enrolled in the Nephrotic Syndrome Study Network (NEPTUNE).

Exposure

The NEPTUNE Digital Pathology Scoring System (NDPSS) was applied to generate scores for 37 glomerular descriptors.

Outcome

Time from biopsy to complete proteinuria remission, time from biopsy to kidney disease progression (40% estimated glomerular filtration rate [eGFR] decline or kidney failure), and eGFR over time.

SUBMITTER: Hodgin JB 

PROVIDER: S-EPMC10795715 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature