Transcranial focused ultrasound to human rIFG improves response inhibition through modulation of the P300 onset latency.

ABSTRACT: Response inhibition in humans is important to avoid undesirable behavioral action consequences. Neuroimaging and lesion studies point to a locus of inhibitory control in the right inferior frontal gyrus (rIFG). Electrophysiology studies have implicated a downstream event-related potential from rIFG, the fronto-central P300, as a putative neural marker of the success and timing of inhibition over behavioral responses. However, it remains to be established whether rIFG effectively drives inhibition and which aspect of P300 activity uniquely indexes inhibitory control-ERP timing or amplitude. Here, we dissect the connection between rIFG and P300 for inhibition by using transcranial-focused ultrasound (tFUS) to target rIFG of human subjects while they performed a Stop-Signal task. By applying

SUBMITTER: Fine JM 

PROVIDER: S-EPMC10796145 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature