Absence of causal relationship between Parkinson's disease and subsequent prostate cancer: evidence from meta-analysis and Mendelian randomization studies.

ABSTRACT:

Background

Numerous observational studies have investigated the risk of prostate cancer (PCa) in patients diagnosed with Parkinson's Disease (PD). However, the existence of a definitive association remains uncertain.

Methods

Systematic searches were performed on PubMed, Web of Science, Scopus, and Google Scholar for studies published up to October 1, 2023. For Mendelian randomized (MR) causal inference, we employed pooled data from the IPDGC and PRACTICAL Consortium. The inverse variance weighted (IVW) method served as the principal technique for estimating odds ratios (ORs) and 95% confidence intervals (CIs) for the associations under investigation.

Results

Cumulative analysis of nine studies revealed no significant association between patients diagnosed with PD and

SUBMITTER: Wang L 

PROVIDER: S-EPMC10796167 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature