Seq-InSite: sequence supersedes structure for protein interaction site prediction.

ABSTRACT:

Motivation

Proteins accomplish cellular functions by interacting with each other, which makes the prediction of interaction sites a fundamental problem. As experimental methods are expensive and time consuming, computational prediction of the interaction sites has been studied extensively. Structure-based programs are the most accurate, while the sequence-based ones are much more widely applicable, as the sequences available outnumber the structures by two orders of magnitude. Ideally, we would like a tool that has the quality of the former and the applicability of the latter.

Results

We provide here the first solution that achieves these two goals. Our new sequence-based program, Seq-InSite, greatly surpasses the performance of sequence-based models, matching the quality of

SUBMITTER: Hosseini S 

PROVIDER: S-EPMC10796176 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature