Exploring potential causal associations between autoimmune diseases and colorectal cancer using bidirectional Mendelian randomization.

ABSTRACT: Several observational studies have revealed an association between autoimmune diseases (AIDs) and colorectal cancer (CRC), although their causal association remained controversial. Therefore, our study used a two-sample Mendelian randomization (MR) analysis to verify the causal association between AIDs and CRC. We employed three common MR approaches, including inverse variance weighted (IVW), weighted median, and MR-Egger methods, to assess the causal association between type 1 diabetes (T1D), systemic lupus erythematosus, rheumatoid arthritis, psoriasis, multiple sclerosis, juvenile idiopathic arthritis, celiac disease, and primary sclerosing cholangitis (PSC) and CRC. The reverse MR analysis was performed to assess the possibility of reverse causation. To evaluate the validity of the ana

SUBMITTER: Chen L 

PROVIDER: S-EPMC10796354 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature