Clinicopathological and prognostic characteristics of idiopathic membranous nephropathy with dual antigen positivity.

ABSTRACT:

Background

Idiopathic membranous nephropathy (IMN) is the most common pathological type in adults with nephrotic syndrome. Many target antigens have been discovered. However, dual antigen-positive IMN patients are very rare, with only a few such cases being briefly described in various studies. There is no specific study on the clinicopathological and prognostic characteristics of dual antigen-positive IMN patients, and the disease characteristics of such patients remain unclear.

Methods

Immunohistochemical staining of PLA2R, THSD7A, and NELL-1 was conducted on kidney tissue samples obtained from patients diagnosed with IMN. Simultaneously, the presence of corresponding serum antibodies was determined. Patients exhibiting positivity for dual antigens were included in the stu

SUBMITTER: Yang L 

PROVIDER: S-EPMC10796489 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature