Plasma levels of autophagy regulator Rubicon are inversely associated with acute coronary syndrome.

ABSTRACT:

Background

The discovery of novel biomarkers that improve current cardiovascular risk prediction models of acute coronary syndrome (ACS) is needed for the identification of very high-risk patients and therapeutic decision-making. Autophagy is a highly conserved catabolic mechanism for intracellular degradation of cellular components through lysosomes. The autophagy process helps maintain cardiac homeostasis and dysregulated autophagy has been described in cardiovascular conditions. Rubicon (Run domain Beclin-1-interacting and cysteine-rich domain-containing protein) is a key regulator of autophagy with a potential role in cardiac stress.

Objectives

The aims of the present study were to assess whether changes in circulating Rubicon levels are associated with ACS and to evalua

SUBMITTER: Grazide MH 

PROVIDER: S-EPMC10796531 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature