Platelets promote human macrophages-mediated macropinocytosis of Clostridioides difficile.

ABSTRACT: Clostridioides difficile is the main causative agent of hospital-acquired diarrhea and the potentially lethal disease, C. difficile infection. The cornerstone of the current therapy is the use of antibiotics, which is not fully effective. The molecular mechanisms, inflammatory conditions and host-immune responses that could benefit the persistence or elimination of C. difficile remain unclear. Macrophages perform different ways of endocytosis as part of their immune surveillance functions and platelets, classically known for their coagulatory role, are also important modulators of the immune system. The aim of this study was to evaluate the endocytosis of vegetative C. difficile by human macrophages and the involvement of platelets in this process. Our results s

SUBMITTER: Barbero AM 

PROVIDER: S-EPMC10796631 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature