Treatment-Resistant Depression in Real-World Clinical Practice: A Systematic Literature Review of Data from 2012 to 2022.

ABSTRACT:

Objective

Real-world evidence in treatment-resistant depression (TRD; commonly defined as non-response to ≥ 2 consecutive treatments at adequate dosage and duration) is lacking. A systematic literature review was conducted to understand disease burden and treatment outcomes for patients with TRD, studied in a real-world setting over the last decade.

Data sources

A literature search was conducted in May 2022 in MEDLINE, Embase, The Cochrane Libraries and PsycINFO, comprising studies published from 2012 to 2022. Bibliographies of all relevant identified systematic reviews and relevant conference proceedings from 2020 to 2022 were manually hand-searched.

Study selection

Real-world studies, including cohort, cross-sectional, case-control, chart review and registry studies

SUBMITTER: Oliveira-Maia AJ 

PROVIDER: S-EPMC10796703 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature