Investigation of genetic determinants of cognitive change in later life.

ABSTRACT: Cognitive decline is a major health concern and identification of genes that may serve as drug targets to slow decline is important to adequately support an aging population. Whilst genetic studies of cross-sectional cognition have been carried out, cognitive change is less well-understood. Here, using data from the TOMMORROW trial, we investigate genetic associations with cognitive change in a cognitively normal older cohort. We conducted a genome-wide association study of trajectories of repeated cognitive measures (using generalised estimating equation (GEE) modelling) and tested associations with polygenic risk scores (PRS) of potential risk factors. We identified two genetic variants associated with change in attention domain scores, rs534221751 (p = 1 × 10^-8 with slope 1)

SUBMITTER: Mahedy L 

PROVIDER: S-EPMC10796929 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature