A modular chemoenzymatic cascade strategy for the structure-customized assembly of ganglioside analogs.

ABSTRACT: Gangliosides play vital biological regulatory roles and are associated with neurological system diseases, malignancies, and immune deficiencies. They have received extensive attention in developing targeted drugs and diagnostic markers. However, it is difficult to obtain enough structurally defined gangliosides and analogs especially at an industrial-relevant scale, which prevent exploring structure-activity relationships and identifying drug ingredients. Here, we report a highly modular chemoenzymatic cascade assembly (MOCECA) strategy for customized and large-scale synthesis of ganglioside analogs with various glycan and ceramide epitopes. We typically accessed five gangliosides with therapeutic promising and systematically prepared ten GM1 analogs with diverse ceramides. Through further

SUBMITTER: Jin X 

PROVIDER: S-EPMC10796935 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature