Impaired lung function in adolescents with pulmonary tuberculosis during treatment and following treatment completion.

ABSTRACT:

Background

Little is known about post-tuberculosis lung disease in adolescents. We prospectively assessed lung function in adolescents with microbiologically confirmed pulmonary tuberculosis during treatment and after treatment completion.

Methods

In a prospective study, we enrolled adolescents diagnosed with microbiologically confirmed tuberculosis and healthy tuberculosis-exposed household controls, between October 2020 and July 2021 in Cape Town, South Africa. Spirometry, plethysmography, diffusion capacity lung function tests and 6-min walking test (6MWT) were completed according to international guidelines 2 months into treatment and following treatment completion. Abnormal lung function was defined as abnormal spirometry (z-score < -1.64 for forced expiratory volume in

SUBMITTER: van der Zalm MM 

PROVIDER: S-EPMC10796966 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature