Re-examining prophylactic cranial irradiation in small cell lung cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Patients with small cell lung cancer (SCLC) are at high risk for brain metastases. Prophylactic cranial irradiation (PCI) is recommended in this population to reduce the incidence of brain metastases and prolong survival. We aimed to assesses the efficacy of PCI in this population in the era of routine brain imaging. To our knowledge, this is the first systematic review and meta-analysis to examine the use among patients who were radiographically confirmed not to have brain metastases after completion of first-line therapy.

Methods

In this systematic review and meta-analysis, cohort studies and controlled trials reporting on the use of PCI for patients SCLC were identified in EMBASE, MEDLINE, CENTRAL, and grey literature sources. The literature search was conducte

SUBMITTER: Gaebe K 

PROVIDER: S-EPMC10796984 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature