Lethal severe fever with thrombocytopenia syndrome virus infection causes systemic germinal centre failure and massive T cell apoptosis in cats.

ABSTRACT:

Introduction

Severe fever with thrombocytopenia syndrome (SFTS) is a fatal viral disease characterized by high fever, thrombocytopenia, leukopenia, and multi-organ haemorrhage. Disruption of the humoral immune response and decreased lymphocyte numbers are thought to contribute to the disease severity. These findings have been obtained through the analysis of peripheral blood leukocytes in human patients, whereas analysis of lymph nodes has been limited. Thus, in this study, we characterized the germinal centre response and apoptosis in the lymph nodes of cats with fatal SFTS, because SFTS in cats well mimics the pathology of human SFTS.

Methods

Lymph node tissue sections collected during necropsy from seven fatal SFTS patients and five non-SFTS cases were used for histopatho

SUBMITTER: Sakai Y 

PROVIDER: S-EPMC10796997 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature