Membrane properties modulation by SanA: implications for xenobiotic resistance in Salmonella Typhimurium.

ABSTRACT:

Introduction

Multidrug resistance in bacteria is a pressing concern, particularly among clinical isolates. Gram-negative bacteria like Salmonella employ various strategies, such as altering membrane properties, to resist treatment. Their two-membrane structure affects susceptibility to antibiotics, whereas specific proteins and the peptidoglycan layer maintain envelope integrity. Disruptions can compromise stability and resistance profile toward xenobiotics. In this study, we investigated the unexplored protein SanA's role in modifying bacterial membranes, impacting antibiotic resistance, and intracellular replication within host cells.

Methods

We generated a sanA deletion mutant and complemented it in trans to assess its biological function. High-throug

SUBMITTER: Aleksandrowicz A 

PROVIDER: S-EPMC10797042 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature