Causal association between colorectal cancer and Alzheimer's disease: a bidirectional two-sample mendelian randomization study.

ABSTRACT: Background: Colorectal cancer and Alzheimer's disease are both common life-threatening diseases in the elderly population. Some studies suggest a possible inverse relationship between colorectal cancer and Alzheimer's disease, but real-world research is subject to many biases. We hope to clarify the causal relationship between the two through a bidirectional two-sample Mendelian randomization study. Methods: In our study, we used genetic summary data from large-scale genome-wide association studies to investigate the relationship between colorectal cancer and Alzheimer's disease. Our primary analysis employed the inverse-variance weighted method and we also used complementary techniques, including MR-Egger, weighted median estimator, and Maximum likelihood. We applied simex a

SUBMITTER: Yuan C 

PROVIDER: S-EPMC10797121 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature