[⁸⁹Zr]-CD8 ImmunoPET imaging of glioblastoma multiforme response to combination oncolytic viral and checkpoint inhibitor immunotherapy reveals CD8 infiltration differential changes in preclinical models.

ABSTRACT: Rationale: Novel immune-activating therapeutics for the treatment of glioblastoma multiforme (GBM) have shown potential for tumor regression and increased survival over standard therapies. However, immunotherapy efficacy remains inconsistent with response assessment being complicated by early treatment-induced apparent radiological tumor progression and slow downstream effects. This inability to determine early immunotherapeutic benefit results in a drastically decreased window for alternative, and potentially more effective, treatment options. The objective of this study is to evaluate the effects of combination immunotherapy on early CD8⁺ cell infiltration and its association with long term response in orthotopic syngeneic glioblastoma models. Methods: Luciferase

SUBMITTER: Gallegos CA 

PROVIDER: S-EPMC10797292 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature