Gut microbiota influences the efficiency of immune checkpoint inhibitors by modulating the immune system (Review).

ABSTRACT: Immune checkpoint inhibitors (ICIs) are commonly utilized in tumor treatment. However, they still have limitations, including insufficient effectiveness and unavoidable adverse events. It has been demonstrated that gut microbiota can influence the effectiveness of ICIs, although the precise mechanism remains unclear. Gut microbiota plays a crucial role in the formation and development of the immune system. Gut microbiota and their associated metabolites play a regulatory role in immune balance. Tumor occurrence and development are linked to their ability to evade recognition and destruction by the immune system. The purpose of ICIs treatment is to reinitiate the immune system's elimination of tumor cells. Thus, the immune system acts as a communication bridge between gut microbiota and ICI

SUBMITTER: Jiang H 

PROVIDER: S-EPMC10797324 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature