Mechanisms of limitation of oxygen delivery during veno-venous extracorporal membrane oxygenation.

ABSTRACT: Delivery of oxygen to the mitochondrium is a process involving multiple steps. We here present the integration of the mechanisms of oxygen delivery (DO₂) during veno-venous (V-V) extracorporal membrane oxygenation (ECMO) into a holistic physiological model. The final steps of oxygen transport in this model are the convective transport of oxygen bound to hemoglobin in the arterial blood and the diffusion to the mitochondrium from the microcirculation. Limitation of DO₂ may occur on both steps. In cases of severe respiratory failure without lung function, ECMO may provide the entire oxygen supply for the patients. If the cardiac output (CO) is significantly higher than the maximal ECMO flow, the addition of deoxygenated venous blood will lead to a low arterial oxygen sa

SUBMITTER: Heymer J 

PROVIDER: S-EPMC10797343 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature