Transcription factor-target gene regulatory network analysis in human lung adenocarcinoma.

ABSTRACT:

Background

Transcription factors (TFs) play a crucial role in the occurrence and progression of lung adenocarcinoma (LUAD), and targeting TFs is an important direction for treating LUAD. However, targeting a single TF often fails to achieve satisfactory therapeutic outcomes. Furthermore, the regulatory TF-target gene networks involved in the development of LUAD is complex and not yet fully understood.

Methods

In this study, we performed RNA sequencing (RNA-seq) to analyze the transcriptome profile of human LUAD tissues and matched adjacent nontumor tissues. We selected the differentially expressed TFs, performed enrichment analysis and survival curve analysis, and predicted the regulatory networks of the top differential TFs with their target genes. Finally, alternative spli

SUBMITTER: Huang F 

PROVIDER: S-EPMC10797383 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature