Impact of guideline therapy on survival of patients with stage I-III epithelioid mesothelioma.

ABSTRACT:

Background

Modern treatment guidelines recommend multimodal therapy with at least chemotherapy and surgery for patients with potentially resectable epithelioid mesothelioma. This study evaluated guideline compliance for patients with stage I-III epithelioid mesothelioma and tested the hypothesis that guideline-concordant therapy improved survival.

Methods

The National Cancer Database was queried for patients with stage I-III epithelioid malignant pleural mesothelioma between 2004 and 2016. The impact of therapy was evaluated using logistic regression, Kaplan-Meier analysis, Cox-proportional hazards analysis, and propensity-scoring methods.

Results

During the study period, guideline-concordant therapy was used in 677 patients (19.1%), and 2,857 patients (80.8%) did not

SUBMITTER: Liou DZ 

PROVIDER: S-EPMC10797401 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature