Neurostimulation for Advanced Parkinson Disease and Quality of Life at 5 Years: A Nonrandomized Controlled Trial.

ABSTRACT:

Importance

Deep brain stimulation of the subthalamic nucleus (STN-DBS) improves quality of life (QOL) in patients with advanced Parkinson disease (PD). However, controlled studies with more than 3 years of follow-up are lacking.

Objective

To investigate the long-term effects of STN-DBS on QOL compared with standard-of-care medication (MED).

Design, setting, and participants

In this prospective, observational, quasi-experimental, longitudinal nonrandomized controlled trial, 183 patients were screened for eligibility and 167 were enrolled from March 1, 2011, to May 31, 2017, at 3 European university centers. Propensity score matching for demographic and clinical characteristics was applied to 108 patients with PD (62 in the STN-DBS group and 46 in the MED group), result

SUBMITTER: Jost ST 

PROVIDER: S-EPMC10797423 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature