Transformation of Black Phosphorus through Lattice Reconstruction for NIR-II-Responsive Cancer Therapy.

ABSTRACT: The photothermal performance of black phosphorus (BP) in the near infrared (NIR)-II bio-window (1000-1500 nm) is low, which limits its biomedical applications. Herein, ultrasmall nickel phosphide quantum dots (Ni₂ P QDs) are synthesized with BP quantum dots (BPQDs) as the template by topochemical transformation. The size of Ni₂ P QDs is ≈3.5 nm, similar to that of BPQDs, whereas the absorption and photothermal conversion efficiency of Ni₂ P QDs at 1064 nm (43.5%) are significantly improved compared with those of BPQDs. To facilitate in vivo applications, an Ni₂ P QDs-based liposomal nano-platform (Ni₂ P-DOX@Lipo-cRGD) is designed by incorporation of Ni₂ P QDs and doxorubicin (DOX) into liposomal bilayers and the interior, re

SUBMITTER: Wu L 

PROVIDER: S-EPMC10797469 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature