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Small Extracellular Vesicles Derived from Altered Peptide Ligand-Loaded Dendritic Cell Act as A Therapeutic Vaccine for Spinal Cord Injury Through Eliciting CD4⁺ T cell-Mediated Neuroprotective Immunity.

ABSTRACT: The balance among different CD4⁺ T cell subsets is crucial for repairing the injured spinal cord. Dendritic cell (DC)-derived small extracellular vesicles (DsEVs) effectively activate T-cell immunity. Altered peptide ligands (APLs), derived from myelin basic protein (MBP), have been shown to affect CD4⁺ T cell subsets and reduce neuroinflammation levels. However, the application of APLs is challenging because of their poor stability and associated side effects. Herein, it is demonstrate that DsEVs can act as carriers for APL MBP_87-99 A⁹¹ (A91-DsEVs) to induce the activation of 2 helper T (Th2) and regulatory T (Treg) cells for spinal cord injury (SCI) in mice. These stimulated CD4⁺ T cells can efficiently "home" to the lesion area and

SUBMITTER: Wang S

PROVIDER: S-EPMC10797491 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature

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Small Extracellular Vesicles Derived from Altered Peptide Ligand-Loaded Dendritic Cell Act as A Therapeutic Vaccine for Spinal Cord Injury Through Eliciting CD4⁺ T cell-Mediated Neuroprotective Immunity.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Small Extracellular Vesicles Derived from Altered Peptide Ligand-Loaded Dendritic Cell Act as A Therapeutic Vaccine for Spinal Cord Injury Through Eliciting CD4+ T cell-Mediated Neuroprotective Immunity.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Small Extracellular Vesicles Derived from Altered Peptide Ligand-Loaded Dendritic Cell Act as A Therapeutic Vaccine for Spinal Cord Injury Through Eliciting CD4⁺ T cell-Mediated Neuroprotective Immunity.