BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis.

ABSTRACT: In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.

SUBMITTER: Acosta-Medina AA 

PROVIDER: S-EPMC10797504 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature