Fecal cytolysin does not predict disease severity in acutely decompensated cirrhosis and acute-on-chronic liver failure.

ABSTRACT:

Background

Cirrhosis with acute decompensation (AD) and acute-on-chronic liver failure (ACLF) are characterized by high morbidity and mortality. Cytolysin, a toxin from Enterococcus faecalis (E. faecalis), is associated with mortality in alcohol-associated hepatitis (AH). It is unclear whether cytolysin also contributes to disease severity in AD and ACLF.

Methods

We studied the role of fecal cytolysin in 78 cirrhotic patients with AD/ACLF. Bacterial DNA from fecal samples was extracted and real-time quantitative polymerase chain reaction (PCR) was performed. The association between fecal cytolysin and liver disease severity in cirrhosis with AD or ACLF was analyzed.

Results

Fecal cytolysin and E. faecalis abundance did not predict chronic liver failure (CLIF-C) AD and

SUBMITTER: Hartmann P 

PROVIDER: S-EPMC10797562 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature