Retrograde procedural memory is impaired in people with Parkinson's disease with freezing of gait.

ABSTRACT:

Background

Freezing of gait (FOG), is associated with impairment of different cognitive functions. Previous studies hypothesized that FOG may be due to a loss of automaticity.

Research question

To explore whether FOG is associated with impairment in cognitive functions, focusing on retrograde procedural memory, the memory responsible for the automatic, implicit stored procedures that have been acquired in earlier life stages.

Methods

In this cross-sectional, case-control study, 288 people with typical Parkinson's disease (PD) from the Luxembourg Parkinson's Study were assigned to Freezers (FOG⁺) and non-Freezers (FOG^-) based on the MDS-UPDRS 2.13 (self-reported FOG episodes) and 3.11 (FOG evaluated by clinicians during gait assessment). Both grou

SUBMITTER: Pauly L 

PROVIDER: S-EPMC10797621 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature